Comprehensive phantom for interventional fluorescence molecular imaging

Interventional Molecular Imaging.

Although molecular imaging has had a dramatic impact on diagnostic imaging, it has only recently begun to be integrated into interventional procedures. Its significant impact is attributed to its ability to provide noninvasive, physiologic information that supplements conventional morphologic imaging. The four major interventional opportunities for molecular imaging are, first, to provide guida...

Quantitative molecular imaging with a dual modality MR and fluorescence diffuse optical imaging system: phantom study

Introduction : Molecular imaging has become an essential tool in characterization and measurement of biological process at the molecular or cellular level. In vivo small animal studies have shown the feasibility of using MRI to investigate gene expression and stem cell migration with superparamagnetic iron nanoparticles [1]. However, even though MRI provides excellent anatomical information, th...

Fluorescence molecular imaging.

There is a wealth of new fluorescent reporter technologies for tagging of many cellular and subcellular processes in vivo. This imposed contrast is now captured with an increasing number of available imaging methods that offer new ways to visualize and quantify fluorescent markers distributed in tissues. This is an evolving field of imaging sciences that has already achieved major advances but ...

Molecular probes for fluorescence lifetime imaging.

Visualization of biological processes and pathologic conditions at the cellular and tissue levels largely relies on the use of fluorescence intensity signals from fluorophores or their bioconjugates. To overcome the concentration dependency of intensity measurements, evaluate subtle molecular interactions, and determine biochemical status of intracellular or extracellular microenvironments, flu...

Evaluation of Reflection Optical Imaging Characteristics Using Fluorescence with Near Infrared Wavelength at Different Depths of Tissue Equivalent Phantom